Chapter 2: Encounter with "Zepbound"

ZepBound: A new hope for treating obesity

Zepbound (tirzepatide) is a revolutionary anti-obesity drug that has been called the "miracle of the 21st century." Its greatest feature is that it can achieve weight loss of 20% or more without strict dietary restrictions.

The mechanism behind the amazing effect

This drug simultaneously enhances the activity of two hormones secreted from the intestines, GLP-1 and GIP. In the SURMOUNT trial (2,539 patients), the ZepBound group achieved a weight loss of 20.9%, compared to 3.1% in the placebo group.

Current situation and issues in Japan

It was released in Japan in April 2025 as a treatment for obesity, but insurance eligibility criteria are strict, forcing many patients to pay for treatment out of pocket, costing 60,000 to 80,000 yen per month.

Superiority over other drugs

In the latest SURMOUNT-5 trial, Zepbound clearly outperformed Ugobi:

• Zepbound: 20.2% weight loss

• Ugobi: 13.7% weight loss

This 6.5% difference is statistically significant and has a favorable side effect profile. Even though effective drugs exist, they are often unavailable for economic reasons. I launched GLP1.com to change this reality.