Telephone reception hours: 8:30-16:30
(Until 13:30 on Saturdays, closed on Sundays and public holidays)
Provided by HDC Atlas Clinic
Physician in charge: Yoshihiko Suzuki, diabetes specialist
What is the GIP/GLP-1 receptor agonist " Zepbound"?
Zepbound was developed as a treatment for type 2 diabetes. It was approved by the US FDA in 2022 as the diabetes treatment "Mounjaro," and subsequently evaluated for its weight loss effects, and was approved by the US FDA in 2023 as the obesity treatment "Zepbound." By enhancing the effects of both GIP and GLP-1, it has been reported to have a greater weight loss effect than conventional GLP-1-only drugs. As such, it has become a new option for the treatment of obesity.
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Active ingredient: Tirzepatide
Tirzepatide is a new type of drug that acts on both GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide).
Mechanism of action
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appetite suppression
How GIP works
GIP promotes the secretion of insulin (a hormone that lowers blood sugar levels) in response to increases in blood sugar levels, resulting in a feeling of fullness after a meal. GIP alone has a relatively weak appetite suppressant effect, so it is further strengthened by combining it with the action of GLP-1.
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Function of GLP-1
GLP-1 acts on the satiety center in the brain and has a powerful effect of suppressing appetite.
Blood sugar control
How GIP works
It stabilizes blood sugar levels by promoting insulin secretion according to post-meal blood sugar levels. It also moderately regulates the secretion of glucagon (a hormone that raises blood sugar levels), creating a state where blood sugar is less likely to rise sharply.
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Function of GLP-1
GLP-1 also promotes insulin secretion and suppresses glucagon secretion, improving blood sugar control.
Slows stomach digestion
How GIP works
GIP has a relatively weak effect on the gastrointestinal tract and is not thought to significantly alter gastric motility.
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Function of GLP-1
GLP-1 slows down stomach activity and helps you feel fuller for longer after a meal, which naturally reduces food intake.
How to use Zepp Bound and precautions
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How to use
Zepbound is a self-injectable medicine that you administer once a week to your stomach, thighs,
It is administered subcutaneously in the arm or other area on the same day each week, starting with a low dose and gradually increasing it so that the body can adapt.
Points to note
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Use on a set schedule
Injecting on the same day every week will ensure consistent results.
If you miss a dose, give it as soon as possible, provided there are at least 48 hours until your next scheduled dose.
Be aware of side effects
You may experience nausea and stomach upset, but this will usually improve once your body gets used to it. If your appetite is too low, don't force yourself to eat, but eat small amounts at a time.
Adjust your diet
Avoiding high-fat and high-calorie foods can help reduce side effects. Drink plenty of fluids and eat a balanced diet.
Be careful of chronic illnesses and interactions with other medications
If you have diabetes, digestive system disorders, or are pregnant, you should consult with your doctor. If you take this medicine in combination with other medications, side effects may be intensified, so be sure to check beforehand.
Zepbound is an effective medication for weight loss and blood sugar control if used correctly. It is important to continue taking it within your limits and follow your doctor's instructions.
The difference between Saxenda and Zeppbound
Both Saxenda and Zepbound are injectable medications for treating obesity, but they have different mechanisms of action and effects.
Ingredients
Saxenda:
The active ingredient is liraglutide. It is a GLP-1 (glucagon-like peptide-1) receptor agonist that acts to regulate blood sugar levels and suppress appetite.
Zepbound:
The active ingredient is tirzepatide. It is a “dual agonist” that acts on both GLP-1 receptors and GIP (glucose-dependent insulinotropic polypeptide) receptors. This dual action is the major difference.
Indications
Saxenda:
Approved for the treatment of obesity. Specifically, it is indicated for adults with obesity (BMI ≥30) or adults with a BMI ≥27 who have weight-related health issues (such as hypertension, type 2 diabetes, etc.).
or higher (obesity), or adults with a BMI of 27 or higher who also have weight-related health issues (such as hypertension or type 2 diabetes).
Zepbound:
Similarly approved as an obesity treatment, it targets adults meeting the same BMI criteria as Saxenda (BMI ≥30 or ≥27 with comorbidities). However, Zepbound is a newer drug reported to have stronger weight loss effects.
Mechanism of Action
Saxenda:
It stimulates only the GLP-1 receptor, promoting weight loss by suppressing appetite and slowing gastric emptying.
It also has blood glucose-lowering effects, but obesity treatment is its primary purpose.
Zepbound:
Acts on both GLP-1 and GIP receptors. The additional GIP effect is expected to improve insulin sensitivity and promote fat breakdown, resulting in stronger appetite suppression than Saxenda.
Administration Method
Saxenda:
A once-daily subcutaneous injection. Treatment starts at a low dose, gradually increasing to balance efficacy and side effects.
Zepbound:
Administered once weekly via subcutaneous injection. The lower frequency reduces burden.
Effectiveness
Saxenda:
Clinical trials report an average weight loss of approximately 5-10%. While individual results vary, it is characterized by gradual weight reduction.
Zepbound:
Clinical trials report an average weight loss exceeding 15-20%, demonstrating greater efficacy than Saxenda. This is due to the potent action of its dual agonist mechanism.
Side Effects
Both medications commonly cause gastrointestinal side effects such as nausea, vomiting, and diarrhea.
However, due to its stronger action, Xepbound may cause more pronounced side effects. Conversely, Saxenda's once-daily dosing allows for gradual adaptation, potentially reducing side effects in some cases.
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Both medications can be used more effectively in combination with diet and lifestyle changes to help you lose weight. It's important to consult with your doctor to choose the treatment that's right for you, taking into account your weight loss goals, your need for blood sugar control, your tolerance for side effects, and your preferred dosing frequency.
Who is Zep Bound suitable for?
Xepbound is a medication suitable for people who want to lose weight or control their blood sugar levels. It is especially recommended for people like the following:
People who want to diet but find it difficult to suppress their appetite
“I want to eat less, but I always end up overeating...” This is perfect for people like that. Zeppbound naturally suppresses appetite, so you can reduce calories effortlessly.
People who find it hard to lose weight no matter what they do
Even for those who struggle to lose weight despite exercise and dietary restrictions, Zeppbound is effective. It helps burn fat and makes weight loss easier.
People at risk of health problems due to obesity
Obesity increases the risk of diabetes, high blood pressure, heart disease, and other conditions. Using Zepp Bound is expected to support appropriate weight management.
People who want to improve their lifestyle habits
Using ZeppBound while reviewing your diet and exercise habits allows for more effective weight loss, making it suitable for those aiming for a healthier lifestyle.
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※Caution is advised for the following individuals!
Pregnant or breastfeeding women
Individuals with gastrointestinal diseases (side effects may include indigestion or nausea)
Individuals taking other medications (combination use may intensify side effects)
Individuals with severe digestive system disorders (may worsen symptoms due to its effect of slowing stomach movement)
Individuals with a history of pancreatitis (GLP-1 receptor agonists may increase the risk of pancreatitis)
Individuals with a family history of medullary thyroid cancer or those with multiple endocrine neoplasia type 2 (MEN2) (Animal studies suggest a risk of thyroid tumors)
Individuals taking diabetes medications (may cause hypoglycemia)
Individuals with pre-existing kidney or liver conditions (may affect drug metabolism or excretion)
Individuals with low blood pressure (risk of further blood pressure decrease due to reduced food intake or dehydration)
Elderly individuals (may experience side effects more readily and face greater physical burden)
Individuals who experienced severe side effects from GLP-1 receptor agonists in the past (caution is required as Zepbound has similar effects)
ZepBound helps regulate food intake and contributes to proper
weight management. It's possible. If you're interested, talk to your doctor!