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SURMOUNT-J study

The SURMOUNT-J trial was a clinical trial conducted on Japanese patients with obesity. It was conducted to verify the efficacy and safety of tirzepatide (Zepbound) in accordance with the constitution and metabolism of Japanese people.

Exam Overview

  • Subjects: Obese Japanese adults (without type 2 diabetes)

  • Methods: Tirzepatide (10 mg or 15 mg) or placebo was administered once weekly for 72 weeks.

  • Evaluation: weight loss effect, metabolic indicators (blood sugar, lipids, etc.), safety

​主な結果

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Weight Loss Effect

10mg group: Average −17.8%

15mg group: Average −22.7%

Placebo group: −1.7%

→ Most patients achieved weight loss of approximately 20%.

 

Percentage achieving ≥5% weight loss

10mg group: 94%

15mg group: 96%

Placebo group: 20%

 

Improvement in Metabolic Parameters

HbA1c decreased by an average of 0.67%

Improvement in fasting blood glucose levels

Enhanced insulin sensitivity

 

Improvement in Cardiovascular Risk Factors

Blood pressure (systolic: decreased by approximately 11-12 mmHg)

Triglycerides (reduced by approximately 50%)

Decreased uric acid levels

 

Improved body fat

Visceral fat: Approximately 40% or more reduction

Subcutaneous fat: Approximately 30% or more reduction

Significant improvement in hepatic fat (Fatty liver improvement rate around 70%)

 

Patient Quality of Life (QOL)

Significant improvement in scores related to physical function and quality of life

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